A new mouse study found that unrepaired DNA-protein crosslinks activate inflammatory signaling pathways that trigger early aging disorders.

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

The structural and functional characteristics of mitochondria shape their role as signaling organelles, with far-reaching ...

Clinical and Preclinical Activity of EGFR Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer Harboring BRAF Class 3 Mutations This was a phase II multicenter trial in which refractory solid ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...